Fig. 10

In vivo activity of CAR T cells in a high tumor burden model. NSG mice (n = 6) were injected i.v. with Raji-luciferase cells on Day 0, and treated with CAR T cells, as indicated in the figure, on day 12. a Disease burden is plotted as the average bioluminescent signal (mean radiance [p/s/cm²/sr]) ± SEM. Groups with less than half of the mice surviving to day 25 are plotted as dotted lines. Groups where more than half survived are plotted as solid lines. b Bioluminescent images of the tumor burden in mice treated with singe and tandem-CAR T constructs as indicated in the plot above on day 25 post tumor engraftment are shown. Red X indicates mice that did not survive to study day 25