Fig. 6

In vivo activity of CAR T constructs. NSG mice were injected i.v. with Raji-luciferase cells on Day 0, and treated with CAR T cells on day 7. a Bioluminescent images of the tumor burden in mice treated with singe and tandem-CAR T constructs on day 6, 14, or 32, post tumor engraftment are shown. Above each group is a listed the CAR-T used for treatment. b Time course of tumor growth based on mouse whole body bioluminescence. 10 mice per CAR T treatment group, and five mice per control group were studied. Mean signal per mouse ± SD is plotted. Statistical analysis for Day 25 (the last time point when subjects in the no treatment control group remained alive) is shown, using two-way ANOVA followed by Dunnett’s multiple comparisons test vs no treatment group. Mean + SD, ***P < 0.001