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Fig. 7 | Journal for ImmunoTherapy of Cancer

Fig. 7

From: GITR ligand fusion protein agonist enhances the tumor antigen–specific CD8 T-cell response and leads to long-lasting memory

Fig. 7

GITRL-FP agonism of GITR and mediation of PD effects in TC-1 tumors. a Tumor volumes were measured in TC-1 tumor–bearing mice vaccinated with vehicle or 3.3 μg of E7 SLP in CpG (Addavax) in the base of the tail. Treated mice received IP doses of GITRL-FP biweekly for 4 total doses. b Kaplan-Meier survival plot of TC-1 tumor bearing mice after treatment with E7 SLP and GITRL-FP To examine PD effects, we evaluated separate groups of mice with identical treatments. Tumors were pooled due to low cell numbers, and spleens were analyzed individually. c CD45+ cells in tumors. d Mouse spleens and tumors were restimulated with 1 μg/mL E7 peptide/protein transport inhibitor for 5 h and stained for IFNγ and TNFα (e) Tregs

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