| |
DFS
|
OS
|
|---|
|
Hazard Ratio
|
P
|
95.0% CI for HR (range)
|
Hazard Ratio
|
P
|
95.0% CI for HR (range)
|
|---|
|
TNM stageb
|
2.180
|
0.009
|
1.219–3.898
|
3.937
|
0.006
|
1.494–10.371
|
|
Signaturesb
|
1.560
|
0.138
|
0.866–2.810
|
2.085
|
0.091
|
0.889–4.890
|
|
Model before stepwise selection
|
|
Agea
|
1.031
|
0.948
|
0.411–2.589
|
4.391
|
0.188
|
0.486–39.703
|
|
T statusb
|
2.613
|
0.010
|
1.255–5.439
|
3.679
|
0.028
|
1.148–11.793
|
|
N stageb
|
1.222
|
0.512
|
0.671–2.225
|
1.125
|
0.815
|
0.420–3.010
|
|
Gradeb
|
1.142
|
0.750
|
0.504–2.585
|
4.189
|
0.027
|
1.180–14.867
|
|
HER-2/neu
|
0.928
|
0.884
|
0.342–2.520
|
0.066
|
0.016
|
0.007–0.066
|
|
Hormone Receptors
|
0.277
|
0.004
|
0.277–0.669
|
0.618
|
0.007
|
0.046–0.621
|
|
Signaturesb
|
2.063
|
0.041
|
1.031–4.126
|
4.850
|
0.014
|
1.374–17.122
|
|
Model after stepwise selection
|
|
T statusb
|
2.999
|
0.001
|
1.602–5.615
|
3.522
|
0.005
|
1.477–8.398
|
|
Hormone Receptors
|
0.269
|
0.002
|
0.116–0.621
|
0.231
|
0.014
|
0.072–0.742
|
|
Signaturesb
|
2.146
|
0.027
|
1.091–4.219
|
4.273
|
0.006
|
1.521–11.999
|
-
aAge under 50 and over 50 years old
-
bAll categorical covariates were transformed into numeric codes as follows: T status (T1; 1, T2; 2, T3; 3), N stage (NO; 0, N1; 1, N2; 2, N3; 3), Grade (G1; 1, G2; 2, G3; 3), Signatures (FCIS; 1, Rest; 2, UCIS; 3) TNM stage (I; 1, II; 2, III; 3)
