Drug(s) | Description | ↑CK? | ASM IgG? | Onset (wks) | Treatment | Trial | Reference |
---|---|---|---|---|---|---|---|
Ipilimumab + nivolumab | Polymyositis with respiratory involvement | Yes | Yes | 3 | Corticosteroid, infliximab, IVIG, Pex | NCT01928394 | [35] |
Nivolumab | Myositis with respiratory failure | Yes | – | 7 | Corticosteroid | – | [36] |
Nivolumab | Myasthenia crisis and polymyositis requiring ventilation | Yes | No | 2 | Corticosteroid, Pex, IVIG pyridostigmine | – | [19] |
Pembrolizumab | Polyarticular tenosynovitis and proximal myositis | No | – | 56 | Sulfasalazine | NCT01295827 | [37] |
Pembrolizumab | Exacerbation of preexisting myositis | Yes | – | 1 | IVIG | – | [38] |
Ipilimumab | Dermatomyositis | Yes | – | 2 | Corticosteroid | – | [39] |
Pembrolizumab / ipilimumab | Rhabdomyolysis associated with hypothyroidism | Yes | – | 6 | Levothyroxine | – | [40] |
Ipilimumab | Combined myasthenia and myositis with AChR | Yes | Yes | 7 | Corticosteroid, IVIG | – | [26] |
Ipilimumab | Retrobulbar weakness with proximal myositis. | Yes | Yes | 7 | Corticosteroid, IVIG | – | [3] |
Ipilimumab | Orbital myositis associated with ipilimumab | – | – | 12 | Corticosteroid | – | [41] |
Tremelimumab + durvalumab | Described in text. | No | Yes | 4 | Corticosteroid, Pex, IVIG | NCT02000947 | Â |