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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Pretreatment antigen-specific immunity and regulation - association with subsequent immune response to anti-tumor DNA vaccination

Fig. 1

Schema of vaccination schedule of two phase I trials in which prostate cancer patients were treated with a DNA vaccine encoding PAP. Panel a: in Trial 1 (NCT00582140), patients received six biweekly immunization. Panel b: In Trial 2 (NCT00849121), patients received six biweekly immunizations followed by booster immunization every 3 months or based on immune monitoring. Grey arrows represent immunization time points. PAP-specific immune responses were monitored every 3 months after the initial six biweekly immunizations for each trial up to one year, as demonstrated by asterisks. Samples obtained before immunization were used for the biomarker analysis. Panel c: Shown are the number of immune responders and non-responders as defined for each trial

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