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Fig. 2: | Journal for ImmunoTherapy of Cancer

Fig. 2:

From: Acute interstitial nephritis after sequential ipilumumab - nivolumab therapy of metastatic melanoma

Fig. 2:

Renal function and corticosteroids. Acute kidney injury appeared after the third cycle of nivolumab. As rehydration was not sufficient, corticosteroids at 0.5 mg/kg/day were initiated. The evolution was marked by functional acute renal injury. At the end of July 2015 creatinine reached 200 μmol/L, olmesartan was discontinued, and with rehydration renal function returned to baseline. Creatinine levels improved and corticosteroids were progressively reduced and then discontinued. Nivolumab was restarted without initial kidney relapse. A new acute renal injury occurred less than two months after discontinuation of corticosteroids

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