Fig. 5
From: Multi-target chimaeric VLP as a therapeutic vaccine in a model of colorectal cancer
MC38-OVA Tumour Trial with Immunotherapeutic Vaccination. The capability of chimaeric RHDV VLP to induce immune responses against subcutaneously engrafted MC38-OVA tumours was investigated with tumour trials. a Tumour engraftment and vaccination protocol, with MC38-OVA tumours engrafted subcutaneously on Day 0, vaccination on days 7, 8 and 9, and rechallenge with MC38-OVA cells in the opposing flank on day 100. b Tumour growth rate and c overall survival following primary challenge of mice vaccinated with T.VP60, S.VP60 and TS.VP60 in comparison to CPBS, VP60 and SIIN.VP60. d The average growth rate of tumours was calculated based on the change in cross-sectional area (mm2) between each measurement divided by the number of days between those measurements. e Comparison of the survival duration amongst tumour-bearing mice between treatment groups. f Determination of tumour escape events, defined as the first positive growth rate measurement following vaccination-induced tumour regression. Results were combined from two independent repeats. Statistical analysis performed using Mantel-Cox log-rank tests for Kaplan-Meier survival curve. NS = Non-significant, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001