TY - JOUR AU - Tosch, Caroline AU - Bastien, Bérangère AU - Barraud, Luc AU - Grellier, Benoit AU - Nourtier, Virginie AU - Gantzer, Murielle AU - Limacher, Jean Marc AU - Quemeneur, Eric AU - Bendjama, Kaïdre AU - Préville, Xavier PY - 2017 DA - 2017/09/19 TI - Viral based vaccine TG4010 induces broadening of specific immune response and improves outcome in advanced NSCLC JO - Journal for ImmunoTherapy of Cancer SP - 70 VL - 5 IS - 1 AB - Advanced non-small cell lung cancer patients receiving TG4010, a therapeutic viral vaccine encoding human Mucin 1 and interleukin-2 in addition to standard chemotherapy, displayed longer overall survival in comparison to that of patients treated with standard chemotherapy alone. Our study intended to establish the association between overall survival and vaccine-induced T cell responses against tumor associated antigens (TAA) targeted by the vaccine. SN - 2051-1426 UR - https://doi.org/10.1186/s40425-017-0274-x DO - 10.1186/s40425-017-0274-x ID - Tosch2017 ER -