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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Viral based vaccine TG4010 induces broadening of specific immune response and improves outcome in advanced NSCLC

Fig. 2

a. Plots of individual responses against 3 known MVA HLA-A02*01-restricted epitopes in the Placebo (n = 31) and TG4010 (n = 47) arms expressed as percentage of positive CD8+ T cells before and after treatment. The percentage of patients with an analytically significant amplification of the response during the treatment course is indicated as a squared figure in each graph. b. Same as in A for 3 known MUC-1 HLA-A02*01-restricted epitopes. c. Representative dot plot example of combinatorial encoded MHC multimer staining for one patient from the TG4010 arm for HLA-A02*01-restricted epitopes of MVA KVDDTFYYV. The x and y axis of dot plots are exponential and fluorescence is given in arbitrary units. Left dot plot displays all CD8+ events; right dot plots are restricted to the two-color positive events. d. Same as in C for HLA-A02*01-restricted epitope of MUC1 VLVCVLVAL. (n.s.: not significant, *: p < 0.05, Mann-Withney U test)

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