Fig. 3
a. Kaplan-Meier plot of survival in patients classified per their response to MUC1 in the TG4010 arm. Patients with no MUC1-specific response (black line, No Resp. Median OS: 11 months, n = 6), patients who had a baseline MUC1-specific response without change upon treatment (blue line, Bsl resp., Median OS: 13 months, n = 24) and patient acquiring a MUC1 response during treatment (red line, Acq Resp Median OS: 32.1 months, n = 16). (*p < 0.05, ns: not significant, Log rank test). b. Kaplan-Meier plot of survival in patients in the TG4010 arm classified per the diversity of response to the MUC1 antigen of TG4010. Patients with no or only one MUC1 epitope specific response (black line, LDMUC1, Median OS: 9.7 months, n = 16). Patients with responses directed against 2 or 3 MUC1 epitopes (red line, HDMUC1, Median OS: 23.5 months, n = 31). (*: p < 0.05, Log rank test). c. Same as in A for patients of the placebo arm. Patients with no MUC1-specific response (black line, No Resp. Median OS: 7.5 months, n = 5), patients who had a baseline MUC1-specific response without change upon treatment (blue line, Bsl resp., Median OS: 14.1 months, n = 15) and patient acquiring a MUC1 response during treatment (red line, Acq Resp Median OS: 15.5 months, n = 11). (ns: not significant, Log rank test). d: Kaplan-Meier plot of survival in patients in the TG4010 arm stratified on the intensity of response against known cytomegalovirus HLA-A02*01-restricted epitope. Patients were stratified based on the response intensity and allocated to the “high” subgroup (blue line, Median OS: 10.4 months, n = 22) when above median or “low” group (green line, Median OS: 12.2 months, n = 25) when below median. (ns: not significant, Log rank test)