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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Checkpoint inhibitor is active against large cell neuroendocrine carcinoma with high tumor mutation burden

Fig. 1

Pathologic findings. a Section from the initial surgical resection specimen shows a malignant neoplasm composed of solid nests of epithelioid cells with large, irregular, hyperchromatic nuclei, occasional prominent nucleoli, and abundant eosinophilic cytoplasm. There are numerous mitotic figures, and necrosis is seen in the centers of some of the tumor nests. b Biopsy of the iliac bone lesion shows metastatic tumor with similar histologic features. Note abundant tumor cell necrosis and fragments of bone within the biopsy. Insets in both panels demonstrate positive immunohistochemical staining for synapthophysin. [200× magnification; bar – 200 μm]

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