Table 1 Genomic Alterations Identified by Hybrid Capture
Gene Alteration | Loss or Gain of Function | Predictor of Response to Pembrolizumab |
|---|---|---|
CD274 (PD-L1) amplification | Gain | Yes |
STK11 S216F and LOH | Loss | Negative predictor |
MYC amplification | Gain | No |
APC E2516 | Loss | No |
RB1 | Loss | No |
TP 53 R158 L | Loss | No |