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Table 2 Adverse events in patients receiving RT plus pembrolizumab (n = 21)

From: Melanoma brain metastases treated with stereotactic radiosurgery and concurrent pembrolizumab display marked regression; efficacy and safety of combined treatment

Adverse Event Grade 1 Grade 2 Grade 3 Grade 4
Diarrhea/nausea 3    
Pruritis/Rash 2 1   
Cardiopulmonary
Hepatitis
 Fatigue 14    
 Headache 2    
 CNS bleeding   1   
(from treated BM)
 Seizure 1 1   
 Cognitive change 2 1   
 Neurologic dysfunction 1 1   
 Perilesional Edema   3 1