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Table 1 A concise summary of significant findings from preclinical studies combining immunotherapy with thermal ablation

From: Immuno-thermal ablations – boosting the anticancer immune response

Significance At A Glance

Radiofrequency Ablation

Survival

Rechallenge

Tumor Volume

Cytolytic Activity

CD4+ Tumor Infiltration

CD8+ Tumor Infiltration

+CpG B [31]

NS

+Ex Vivo Stimulated Dendritic Cells [38, 46]

+Poxviral CEA/TRICOM Vaccine [40]

NS

+CC Chemokine Ligand 3 [41]

+Anti-CTLA-4 Antibodies [10]

+Anti-CD25 Antibodies [10]

`−

+Anti-PD-1 Antibodies [16]

Cryoablation

Survival

Rechallenge

MHC I Presentation

MHC II Presentation

CD4+ Tumor Infiltration

CD8+ Tumor Infiltration

+CpG ODN [12]

+Ex Vivo Immature Dendritic Cells [37]

+ TLR7 Agonist Imiquimod [11]

Anti-CTLA-4 Antibodies [10, 15]

Anti-CD25 Antibodies [10]

+Cyclophosphamide [44]

Microwave Ablation

Survival

Rechallenge

Tumor Volume

Th1/Th2 Cytokine Ratio

CD4+ Tumor Infiltration

CD8+ Tumor Infiltration

+OK 432 [42]

+GM-CSF Microspheres [45]

+GM-CSF Microspheres & Anti-CTLA-4 Antibodies [45]

  1. ↑ Significantly improved response (p < 0.05), ↓ significant decrease (p < 0.05), NS not significant