From: Immuno-thermal ablations – boosting the anticancer immune response
Significance At A Glance | ||||||
---|---|---|---|---|---|---|
Radiofrequency Ablation | Survival | Rechallenge | Tumor Volume | Cytolytic Activity | CD4+ Tumor Infiltration | CD8+ Tumor Infiltration |
+CpG B [31] | ↑ | NS | – | ↑ | – | – |
↑ | – | ↓ | ↑ | ↑ | ↓ | |
+Poxviral CEA/TRICOM Vaccine [40] | NS | – | ↓ | – | – | – |
+CC Chemokine Ligand 3 [41] | – | – | ↓ | – | ↑ | ↑ |
+Anti-CTLA-4 Antibodies [10] | – | ↑ | – | – | – | – |
+Anti-CD25 Antibodies [10] | – | ↑ | – | – | – | `− |
+Anti-PD-1 Antibodies [16] | ↑ | – | ↓ | – | – | – |
Cryoablation | Survival | Rechallenge | MHC I Presentation | MHC II Presentation | CD4+ Tumor Infiltration | CD8+ Tumor Infiltration |
+CpG ODN [12] | ↑ | ↑ | ↑ | ↑ | – | – |
+Ex Vivo Immature Dendritic Cells [37] | ↑ | ↑ | – | – | – | – |
+ TLR7 Agonist Imiquimod [11] | – | ↑ | – | – | – | – |
↑ | ↑ | – | – | ↑ | ↑ | |
Anti-CD25 Antibodies [10] | – | ↑ | – | – | – | – |
+Cyclophosphamide [44] | ↑ | ↑ | – | – | – | – |
Microwave Ablation | Survival | Rechallenge | Tumor Volume | Th1/Th2 Cytokine Ratio | CD4+ Tumor Infiltration | CD8+ Tumor Infiltration |
+OK 432 [42] | ↑ | ↑ | – | ↑ | ↑ | ↑ |
+GM-CSF Microspheres [45] | – | ↑ | ↓ | – | – | – |
+GM-CSF Microspheres & Anti-CTLA-4 Antibodies [45] | ↑ | ↑ | ↓ | – | – | – |