ALL Patients (n = 30) | ||
---|---|---|
Total | Grade3/4/5 | |
All adverse events | ||
Any event | 30 (100) | 21 (70) |
Hepatotoxicity | ||
high ALT | 4 (13) | 2 (7) |
Gastrointestinal Disorders | ||
nausea | 21 (70) | 1 (3) |
vomiting | 14 (47) | 0 |
diarrhea | 23 (77) | 3 (10) |
C. difficile colitis | 1 (3) | 1 (3) |
Electrolyte | ||
hypophosphatemia | 4 (13) | 2 (7) |
hypokalemia | 6 (20) | 1 (3) |
hypomagnesemia | 8 (27) | 1 (3) |
Hematological | ||
anemia | 4 (13) | 2 (7) |
febrile neutropenia | 2 (7) | 2 (7) |
neutropenia | 8 (27) | 5 (17) |
thrombocytopenia | 6 (20) | 3 (10) |
Nervous System | ||
seizure | 2 (7) | 1 (3) |
vasovagal reaction | 1 (3) | 1 (3) |
Infection | ||
pneumonia | 1 (3) | 1 (3) |
Constitutional | ||
fatigue | 17 (57) | 2 (7) |
Vascular Disorder | ||
pulmonary embolism | 1 (3) | 1 (3) |
Immune-related adverse events | ||
Any event | 26 (87) | 4 (13) |
Gastrointestinal Disorders | ||
diarrhea | 11 (37) | 2 (7) |
vomiting | 6 (20) | 0 |
autoimmune colitis | 1 (3) | 1 (3) |
Endocrine | ||
hypothyroidism | 1 (3) | 0 |
pituitary disorder | 1 (3) | 0 |
Skin Disorders | ||
rash | 7 (23) | 0 |
pruritus | 9 (30) | 0 |
urticaria | 1 (3) | 0 |
vitiligo | 1 (3) | 0 |
erythroderma | 1 (3) | 0 |
Constitutional | ||
fatigue | 11 (37) | 1 (3) |