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Table 1 Breast cancer related peptides employed in the 9 peptide vaccine and the tetanus peptide adjuvant

From: A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer

Allele

Sequence

Epitope

HLA-A1

EADPTGHSY

MAGE-A1 161–169

 

EVDPIGHLY

MAGE-A3 168–176

HLA-A2

KIFGSLAFL

Her-2/neu 369–377

 

YLSGADLNL

CEA 571–579*

 

GLYDGMEHL

MAGE-A10 254–262

HLA-A3

HLFGYSWYK

CEA 27–35

 

VLRENTSPK

Her-2/neu 754–762

 

SLFRAVITK

MAGE-A1 96–104

HLA-A3/HLA-A31

ASGPGGGAPR

NY-ESO-1 53–62

Tetanus toxoid-derived helper peptide

Binds to multiple class II alleles

AQYIKANSKFIGITEL

p2830–844**

  1. *Asparagine to aspartic acid change at position 576
  2. **An alanine residue was added to the N-terminus to prevent cyclization