Fig. 1

Percentage of patients with adverse events in checkpoint inhitor clinical trials. Circles represent individual clinical trials and size of the circles represent the number of patients enrolled in the study (larger the circle equals greater number of patients). a: AST elevation of any grade. b: AST elevation grade 3–4. c: ALT elevation of any grade. d: ALT elevation grade 3–4. e: Diarrhea of any grade. f: Diarrhea grade 3–4. g: Patients taken off therapy secondary to drug toxicity. h: Patients died secondary to therapy. HCC: Hepatocellular Carcinoma, NSCLC: Non-small cell lung cancer, AST: aspartate aminotransferase, ALT: alanine aminotransferase