Table 3 Sample statistics on proportions of patients in N trials with adverse events as shown. P-values are by an exact form of the Kruskal-Wallis test for comparison of the trial results among all three disease types, while they are by an exact form of the Wilcoxon rank sum test for comparison of trial results between HCC and NSCLC or melanoma
| Â | Â | Â | Â | Â | Â | Â | Â | Overall Comparison | HCC vs NSCLC | HCC vs melanoma |
|---|---|---|---|---|---|---|---|---|---|---|
Disease | Variable | Mean | N | Standard Error | Lower Quartile | Median | Upper Quartile | p-value | p-value | p-value |
HCC | Taken off therapy secondary to toxicity | 0.10 | 3 | 0.04 | 0.03 | 0.13 | 0.15 | 0.48 | 0.39 | 0.96 |
Death secondary to therapy | 0.00 | 3 | 0.00 | 0.00 | 0.00 | 0.00 | 0.12 | 0.11 | 0.34 | |
Elevation AST any grade | 0.38 | 3 | 0.17 | 0.10 | 0.34 | 0.70 | 0.0051 | 0.036 | 0.011 | |
Elevation AST grade 3–4 | 0.24 | 3 | 0.12 | 0.05 | 0.22 | 0.45 | 0.0096 | 0.036 | 0.0028 | |
Elevation ALT any grade | 0.28 | 3 | 0.14 | 0.09 | 0.19 | 0.55 | 0.0083 | 0.036 | 0.022 | |
Elevation ALT grade 3–4 | 0.12 | 3 | 0.07 | 0.03 | 0.09 | 0.25 | 0.0067 | 0.036 | 0.0055 | |
Diarrhea any grade | 0.16 | 3 | 0.07 | 0.06 | 0.12 | 0.30 | 0.00079 | 0.71 | 0.11 | |
Diarrhea grade 3–4 | 0.02 | 3 | 0.02 | 0.00 | 0.01 | 0.05 | 0.12 | 0.96 | 0.25 | |
NSCLC | Taken off therapy secondary to toxicity | 0.06 | 5 | 0.02 | 0.05 | 0.05 | 0.07 | Â | Â | Â |
Death secondary to therapy | 0.01 | 5 | 0.00 | 0.00 | 0.01 | 0.01 | Â | Â | Â | |
Elevation AST any grade | 0.02 | 5 | 0.01 | 0.02 | 0.02 | 0.03 | Â | Â | Â | |
Elevation AST grade 3–4 | 0.00 | 5 | 0.00 | 0.00 | 0.00 | 0.00 |  |  |  | |
Elevation ALT any grade | 0.02 | 5 | 0.00 | 0.02 | 0.02 | 0.03 | Â | Â | Â | |
Elevation ALT grade 3–4 | 0.00 | 5 | 0.00 | 0.00 | 0.00 | 0.00 |  |  |  | |
Diarrhea any grade | 0.10 | 6 | 0.01 | 0.08 | 0.08 | 0.01 | Â | Â | Â | |
Diarrhea grade 3–4 | 0.02 | 6 | 0.01 | 0.01 | 0.01 | 0.03 |  |  |  | |
Melanoma | Taken off therapy secondary to toxicity | 0.11 | 16 | 0.03 | 0.05 | 0.09 | 0.14 | Â | Â | Â |
Death secondary to therapy | 0.01 | 16 | 0.00 | 0.00 | 0.00 | 0.01 | Â | Â | Â | |
Elevation AST any grade | 0.04 | 11 | 0.01 | 0.02 | 0.04 | 0.04 | Â | Â | Â | |
Elevation AST grade 3–4 | 0.01 | 11 | 0.00 | 0.00 | 0.00 | 0.01 |  |  |  | |
Elevation ALT any grade | 0.05 | 11 | 0.02 | 0.03 | 0.04 | 0.05 | Â | Â | Â | |
Elevation ALT grade 3–4 | 0.01 | 11 | 0.00 | 0.00 | 0.01 | 0.01 |  |  |  | |
Diarrhea any grade | 0.30 | 16 | 0.04 | 0.17 | 0.31 | 0.41 | Â | Â | Â | |
Diarrhea grade 3–4 | 0.07 | 16 | 0.02 | 0.01 | 0.05 | 0.13 |  |  |  |