Fig. 2

Tumor mutation burden as a biomarker for anti-PD-1/PD-L1 therapy. a Kaplan-Meier estimate of overall survival according to estimated mutational burden by quartiles in mUC patients treated with atezolizumab in IMVigor 210 – Cohort I. Range estimates next to each qauartile indicated number of mutations per megabase for each quartile. b Quantification of mutation burden across TCGA subtypes and PD-L1 immune cell IHC status and correlation with disease status. c and d Progression-free survival based on tertile of tumor mutation burden from Checkmate 026, a randomized study of nivolumab (c) compared to standard of care chemotherapy (d). A and B reprinted from The Lancet, Vol. 389, Balar et al. “Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicenter, phase 2 trial, p. 73, 2017 with permission from Elsevier [10]. C and D reproduced with permission from Carbone, D. et al. NEJM. 2017., [48]