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Table 1 Characteristics of DRibble preparations

From: A pilot study of an autologous tumor-derived autophagosome vaccine with docetaxel in patients with stage IV non-small cell lung cancer

 

Antigensa

DAMPs

Patient ID

Tumor #

# vac given

Tumor Cell Eq/vaccine

∝g Protein/vaccine

P62

NPM1

KPNA2

LDHB

ENO1

PKM2

HSP90

HSP70

CALR

Patient 2

LT80

2

1.32E + 07

730

++

+++

ND

ND

+++

ND

+

+

+++

Patient 3

LT79

3

1.65E + 07

125

+

ND

ND

ND

+++

ND

ND

+++

+

Patient 5

LT84

4

2.10E + 07

560

+++

+

ND

+++

+

+

ND

+++

+

Patient 6

LT96

2

4.00E + 07

480

+++

+++

+

ND

+++

+++

+

+++

+++

  1. DRibble vaccine was produced from autologous tumor and protein content was determined by the bicinchoninic acid assay (BCA). Proteins were identified by Western Blot and assigned plus symbols based on intensity of the blot (NPM1 nucleophosmin, KPNA2 karyopherin alpha 2, LDHB lactate dehydrogenase B, ENO1 enolase 1); PKM2 pyruvate kinase isozymes M1/M2, HSP Heat-shock protein, CALR Calreticulin. ND: Not Determined. aAntigens detected by Western blot
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