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Table 1 Characteristics of DRibble preparations

From: A pilot study of an autologous tumor-derived autophagosome vaccine with docetaxel in patients with stage IV non-small cell lung cancer

  Antigensa DAMPs
Patient ID Tumor # # vac given Tumor Cell Eq/vaccine g Protein/vaccine P62 NPM1 KPNA2 LDHB ENO1 PKM2 HSP90 HSP70 CALR
Patient 2 LT80 2 1.32E + 07 730 ++ +++ ND ND +++ ND + + +++
Patient 3 LT79 3 1.65E + 07 125 + ND ND ND +++ ND ND +++ +
Patient 5 LT84 4 2.10E + 07 560 +++ + ND +++ + + ND +++ +
Patient 6 LT96 2 4.00E + 07 480 +++ +++ + ND +++ +++ + +++ +++
  1. DRibble vaccine was produced from autologous tumor and protein content was determined by the bicinchoninic acid assay (BCA). Proteins were identified by Western Blot and assigned plus symbols based on intensity of the blot (NPM1 nucleophosmin, KPNA2 karyopherin alpha 2, LDHB lactate dehydrogenase B, ENO1 enolase 1); PKM2 pyruvate kinase isozymes M1/M2, HSP Heat-shock protein, CALR Calreticulin. ND: Not Determined. aAntigens detected by Western blot