Fig. 3

Arginase inhibition reduces tumor growth in vivo. a CB-1158, dosed at 100 mg/kg twice daily, reduced tumor growth as a single agent in multiple syngeneic mouse models of cancer (N = 10 per group). b Mice lacking Arg1 gene expression in the myeloid compartment (indicated as ARG1^ΔM) grow smaller tumors than mice containing wild-type Arg1 (indicated as ARG1^WT), and treatment of ARG1^ΔM mice with CB-1158 does not further reduce tumor growth, indicating on-target activity of CB-1158 (N = 16 per group). (T test: **** P < 0.0001; * P < 0.05)