Fig. 2

Tumor growth by 13 days with both TEM and M2 macrophage subtypes present (same description of panels as in Fig. 1). The M2 macrophages penetrate into the tumor following the gradient of macrophage chemoattractants, with their distribution more scattered than the M1 in the vicinity of the tumor due to the monocyte contact with the TEM-eluted IL-10. The tumor is substantially larger than in Fig. 1, and has more hypoxia