Skip to main content

Table 2 Description of macrophage-associated parameters

From: Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment

Parameter Description Value Reference
Physiological Parameters
% of macrophages per tumor total cells 10% Calibrated to match [11]
TEM-driven tumor neovasculature increase 4-fold [12]
TEM portion of differentiated macrophages 55–70% [13]
M2/M1 ratio in highly metastatic tumors 2.06 [47]
M2/M1 ratio in moderately metastatic tumors 0.77 [47]
Vessel Radius-Associated Parameters Related to TEM Effects
k s Natural shrinking tendency of vessel radius 2.24 [39]
k PC Response rate of radius to tumor pressure 0.76 [39]
Macrophage-Associated Parameters Related to Tumor Growth
λ M Tumor native proliferation rate (day−1) 0.5 Calibrated to match [11]
λ OL Recovery rate of quiescent oxygen level 0.05(*) Calibrated to match [36]
λ OT M2 induced lowering viable O2 threshold rate 200 /s Calibrated to match [36]
λ rec Recovery rate of λM2to zero 0.1(*) Calibrated to match [36]
λ F M2 induced proliferation rate 1000 /s Calibrated to match [36]
λ NO M1 nitric oxide induced death rate 3 /s Calibrated to match [8]
G N Cell degradation rate in the necrotic region 0.3(*) Calibrated to match [11]
Macrophage Differentiation Scaling Coefficients
k M1 Differentiation of M1 macrophage 20 [36]
k M2 Differentiation of M2 macrophage 20 [36]
k T2 Differentiation of TEM 8.21 [13]
k Ang2 Effect of Ang2 on TEM differentiation 0.95 Calibrated to match [1, 13]
k T2M2 Effect of IL-10 on M2 differentiation 0.006 Calibrated to match [47]
Macrophage Movement Scaling Coefficients
M O Effect of oxygen on macrophage movement 1000 [11]
M P Effect of oxygen on macrophage movement 350 [11]
M C Chemotactic macrophage movement 500 [11]
M Ang2 Effect of Ang2 on TEM movement 1000 Calibrated to match [16]
  1. (*) Value is non-dimensionalized by the diffusivity of oxygen [68] (1 × 10−5 cm2 s−1)