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Table 3 Characteristics of the macrophage-associated cytokines used in this study. The M1f characteristics were chosen to be similar to IL-6, while the M2f characteristics were chosen similar to IL-10

From: Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment

Cytokine Function Source MW (Da) Diffusivity (as fraction of TAF diffusivity)
M1f M1 differentiation Proliferating & hypoxic tumor cells 21,000 1
M2f M2 differentiation Proliferating & hypoxic tumor cells 18,606 3.7606
IL-10 TEM-eluted factor TEM 18,606 3.7606
T2f TEM differentiation Proliferating & hypoxic tumor cells 60,179 1
Ang2 TEM chemoattractant Neovasculature ~70,000 0.26591