Table 3 Characteristics of the macrophage-associated cytokines used in this study. The M1f characteristics were chosen to be similar to IL-6, while the M2f characteristics were chosen similar to IL-10
From: Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment
Cytokine | Function | Source | MW (Da) | Diffusivity (as fraction of TAF diffusivity) |
|---|---|---|---|---|
M1f | M1 differentiation | Proliferating & hypoxic tumor cells | 21,000 | 1 |
M2f | M2 differentiation | Proliferating & hypoxic tumor cells | 18,606 | 3.7606 |
IL-10 | TEM-eluted factor | TEM | 18,606 | 3.7606 |
T2f | TEM differentiation | Proliferating & hypoxic tumor cells | 60,179 | 1 |
Ang2 | TEM chemoattractant | Neovasculature | ~70,000 | 0.26591 |