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Table 4 Macrophage-associated cytokine parameters based on proteomic analysis in Frieboes et al. [48]

From: Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment

Parameter Function Value
\( {\overline{\lambda}}_{circulation}^C \) Wash-out rate into vasculature 0.006 (*)
\( {\overline{\lambda}}_{decay}^C \) Decay rate 0.001 (*)
D M1f Diffusivity for M1f 0.005 (*)
D M2f Diffusivity for M2f 0.01880 (*)
D IL − 10 Diffusivity for IL-10 0.01880 (*)
D T2f Diffusivity for T2f 0.005 (*)
D Ang2 Diffusivity for Ang2 0.00133 (*)
\( {\overline{\lambda}}_{production}^{M1f} \) production rate of M1f 1.0 (**)
\( {\overline{\lambda}}_{production}^{M2f} \) production rate of M2f 1.0 (**)
\( {\overline{\lambda}}_{production}^{IL-10} \) production rate of IL-10 1.0 (**)
\( {\overline{\lambda}}_{production}^{T2f} \) production rate of T2f 1.0 (**)
\( {\overline{\lambda}}_{production}^{Ang2} \) production rate of Ang2 1.0 (**)
  1. The same wash-out and decay rates apply to all cytokines, generically denoted by C. (*) Value is non-dimensionalized by the diffusivity of oxygen [68] (1 × 10−5 cm2 s−1). (**) Value is rescaled by the production rate of VEGF-A (VEGF -165) protein, representing a typical TAF molecule