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Table 4 Macrophage-associated cytokine parameters based on proteomic analysis in Frieboes et al. [48]

From: Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment

Parameter

Function

Value

\( {\overline{\lambda}}_{circulation}^C \)

Wash-out rate into vasculature

0.006 (*)

\( {\overline{\lambda}}_{decay}^C \)

Decay rate

0.001 (*)

D M1f

Diffusivity for M1f

0.005 (*)

D M2f

Diffusivity for M2f

0.01880 (*)

D IL − 10

Diffusivity for IL-10

0.01880 (*)

D T2f

Diffusivity for T2f

0.005 (*)

D Ang2

Diffusivity for Ang2

0.00133 (*)

\( {\overline{\lambda}}_{production}^{M1f} \)

production rate of M1f

1.0 (**)

\( {\overline{\lambda}}_{production}^{M2f} \)

production rate of M2f

1.0 (**)

\( {\overline{\lambda}}_{production}^{IL-10} \)

production rate of IL-10

1.0 (**)

\( {\overline{\lambda}}_{production}^{T2f} \)

production rate of T2f

1.0 (**)

\( {\overline{\lambda}}_{production}^{Ang2} \)

production rate of Ang2

1.0 (**)

  1. The same wash-out and decay rates apply to all cytokines, generically denoted by C. (*) Value is non-dimensionalized by the diffusivity of oxygen [68] (1 × 10−5 cm2 s−1). (**) Value is rescaled by the production rate of VEGF-A (VEGF -165) protein, representing a typical TAF molecule