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Table 1 Neuro-oncology evaluation

From: Inflammatory demyelinating polyneuropathy versus leptomeningeal disease following Ipilimumab

Laboratory test

Value

Normal

Units

Blood

 TSH

2.11

0.55–4.78

mcIU/mL

 CK

91

49–397

Unit/L

 WBC

11.7

4.2–9.1

K/uL

 Vitamin B12

587

211–911

Pg/mL

CSF

 Initial

  WBC

1

0–5

Cells/uL

  RBC

0

0

Cells/uL

  Protein

> 300

15–45

Mg/dL

  Glucose

73

40–70

Mg/dL

  Cytology

Negative for malignant cells

  

 6 month Follow-up

  WBC

3

0–5

Cells/uL

  RBC

6

0

Cells/uL

  Protein

169

15–45

Mg/dL

  Glucose

56

40–70

Mg/dL

  Cytology

atypical cells with hyperchromatic nuclei and pigmentation, suspicious for melanoma

  

 Autoimmune Studies

  Asialo-GM1 (IgG/IgM)

13

0–50

IV

  GM2 (IgG/IgM)

4

0–50

IV

  GD1a (IgG/IgM)

8

0–50

IV

  GD1b (IgG/IgM)

4

0–50

IV

  GQ1b (IgG/IgM)

5

0–50

IV

  GM-1 (IgG)

3

0–50

IV

  GM-1 (IgM)

5

0–50

IV

  AMA

1.5

0–20

Units

  Rheumatoid Factor

<  20

<  20

IU/mL

  ANCA

<  1:20

<  1:20

 

  dsDNA antibody

Negative

  

  ENA

Negative

  

  Borrelia burgdorferi antibody

0.20

0–1.20

LIV

  Leishmania antibody IgG

0

0

units

 Hepatitis panel

  Hepatitis B surface antigen

Negative

  

  Hepatitis B surface antibody

0.04a

 

mIU/mL

  Hepatitis B core antibody

Negative

  

  Hepatitis C antibody

Negative

  

 Viral studies

  CMV antibody

Positive

  

  EBV nuclear antigen

Positive

  

  EBV viral capsid antigen IgG

Positive

  

  EBV viral capsid antigen IgM

Negative

  

  HIV

Negative

  

  Herpes 1 IgG

Negative

  

  Herpes 2 IgG

Negative

  
  1. Abbreviations: TSH thyroid stimulating hormone, CK creatinine kinase, WBC white blood cell, RBC red blood cell, GM monosialoganglioside, GD disialoganglioside, GQ tetrasialoganglioside, ENA extractable nuclear antigen screen, ANCA anti-neutrophil cytoplasmic antibody, dsDNA double stranded DNA, AMA Mitochondrial M2 antibody IgG, CMV Cytomegalovirus, EBV Epstein-Barr virus, HIV human immunodeficiency virus, IV index value, LIV Lyme index value
  2. aHepatitis B surface antibody < 8 mIU/mL indicates inadequate antibody response to vaccination