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Table 1 Patient demographics and disease characteristics at baseline (Safety population)

From: A randomized, controlled trial evaluating the efficacy and safety of BTH1677 in combination with bevacizumab, carboplatin, and paclitaxel in first-line treatment of advanced non-small cell lung cancer

  BTH1677/
Bevacizumab/Carboplatin/
Paclitaxel
(N = 59)
Bevacizumab/
Carboplatin/
Paclitaxel
(N = 30)
Age (years)
 Median (range)a 59 (43, 76) 58 (28, 75)
Sex, n (%)
 Male 26 (44.1) 14 (46.7)
 Female 33 (55.9) 16 (53.3)
Race, n (%)
 White 57 (96.6) 30 (100.0)
 Black 1 (1.7) 0
 Asian or Pacific Islander 1 (1.7) 0
ECOG Performance Status, n (%)
 0 31 (52.5) 20 (66.7)
 1 28 (47.5) 10 (33.3)
Disease stage at randomization
 Stage IIIB 0 0
 Stage IV 59 (100.0) 30 (100.0)
Time from initial tumor diagnosis to diagnosis of stage IIIB/IV NSCLC (days)b
 Median (range) 0 (0, 3158) 0 (0, 0)
Time from diagnosis of stage IIIB/IV NSCLC to randomization (days)c
 Median (range) 18 (1, 168) 17.5 (7, 77)
Time from initial tumor diagnosis to randomization (days)d
 Median (range) 20 (1, 3171) 17.5 (7, 77)
Prior cancer treatment, n (%)
 Radiotherapy 2 (3.4) 0
 Surgery 8 (13.6) 2 (6.7)
 Chemotherapy, hormonal, or othere 2 (3.4) 0
  1. Abbreviations: ECOG Eastern Cooperative Oncology Group, N overall sample size, n number of patients, NSCLC non-small cell lung cancer
  2. aInclusion criteria restricted patients to 18 to 75 years of age but one 76-year-old patient was inadvertently enrolled in the study
  3. bTime from initial tumor diagnosis to diagnosis of Stage IIIB/IV NSCLC = Stage IIIB/IV diagnosis date - initial tumor diagnosis date
  4. cTime from diagnosis of Stage IIIB/IV NSCLC to randomization = Date of randomization - Stage IIIB/IV diagnosis date
  5. dTime from initial tumor diagnosis to randomization = Date of randomization –initial tumor diagnosis date
  6. eTwo patients in the BTH1677 arm received prior chemotherapy for lung cancer. Both patients were previous responders and received the prior chemotherapy greater than 6 months prior to enrollment