Fig. 1

Image analysis (IA) scheme and manual annotations of tumor regions. Key processes in the overall IA scheme leading to data production are depicted (a). Tumor regions of images of nonclinical samples were manually annotated by a pathologist to partition invasive margin (IM) from tumor center (TC). Shown is an NSCLC image (b) to which annotations (c) were applied, along with excluded areas (EA) used to omit necrotic areas or other interfering histological features