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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Fig. 2

Validation of image analysis (IA) classification and enumeration of CD8+ TILs. Unclassified images (a) were examined by pathologists at high magnification, and immunolabeled TILs were annotated in purple (b). The IA software then characterized each cell (c) as true positive (blue), false positive (red), or false negative (orange). For clinical trial NCT01693562, concordance between IA and each of three pathologists (d) was determined. For nonclinical samples, concordance between IA and one pathologist was determined and compared, using three statistical measures for all nine tumor types (e)

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