Fig. 5

Paired density plot of CD8+ TILs in tumor center (TC) and invasive margin (IM) across cancer indications (1/mm²). CD8+ TILs in the TC and IM were compared. For each nonclinical specimen, CD8+ TIL densities were determined separately in annotated tumor regions as shown in Fig. 1c. Individual TC scores are plotted as dots and connected to the applicable IM score by a line. Median values for each are shown. For each tumor type, the Wilcoxon T values denote the degree of statistical difference between TC and IM CD8+ TIL densities. Some specimens without an identifiable IM are represented by isolated dots for TC (eg, pancreatic carcinoma). DLBCL is not shown because CD8+ TILs were not enumerated in the IM, as explained in the text