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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Fig. 5

Model-based simulations predicting mechanistic features distinguishing ‘responders’ (animals exhibiting tumor rejection; green lines) vs. ‘non-responders’ (animals exhibiting, ultimately, tumor progression; red lines). Green and red simulation curves correspond, respectively, to individuals with S L values of 1.77 and 22.63 RU, which represent the 10th and 90th percentiles of the S L parameter value distribution. Dashed grey lines correspond to typical individuals with an S L value of 6.95 (the median of the S L parameter value distribution). DC m ; Ag sys ; dT eff ; ISC levels in tumor. All treatments started at Day 7 post tumor implantation

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