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Fig. 6 | Journal for ImmunoTherapy of Cancer

Fig. 6

From: Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Fig. 6

Model simulations of various dose scheduling and sequencing in RT + anti-PD-L1 combination therapies. Panels a-c Efficacy simulation results, summarized as percentages of ‘responders’ (animals exhibiting full tumour rejection; defined as a total tumor volume ≤ 10 mm3 on Day 50 following treatment start), median (values in brackets), based on 1000 virtual studies with 100 animals per study, respective 90% CI are shown in Additional file 1: Table S2. Panels d-f Simulations of corresponding maximal DC m level. Panels g-i Simulations of corresponding dT eff . Panels a, d, g – RT started on Day 5 after injection of tumor cells; Panels b, e, h – RT started on Day 7 after tumor cell injection; Panels c, f, i – RT started on Day 12 after tumor cell injection. Confidence intervals are provided in Additional file 1:Table S2

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