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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Prime-boost vaccination targeting prostatic acid phosphatase (PAP) in patients with metastatic castration-resistant prostate cancer (mCRPC) using Sipuleucel-T and a DNA vaccine

Fig. 5

IgG antibodies elicited recognize different epitopes in different patients. a 16-mer peptides spanning the amino sequence of PAP were evaluated for IgG antibody response by high-throughput immunoblot. Shown is the relative reactivity (FI, fluorescence intensity) to individual peptides using sera obtained pre-treatment (blue) or at 6 months (red) to each peptide for four separate patients treated in Arm 2. b ELISA was used to detect IgG to each of 3 15-mer peptides (beginning at amino acids 201, 205, or 209) or to the full-length PAP protein at the indicated time points. Shown are the mean and standard deviation of triplicate measurements of the Δ O.D. made using sera from patient ID010

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