TY - JOUR AU - Albores-Saavedra, J. AU - Batich, K. AU - Chable-Montero, F. AU - Sagy, N. AU - Schwartz, A. M. AU - Henson, D. E. PY - 2010 DA - 2010// TI - Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study JO - J Cutan Pathol VL - 37 UR - https://doi.org/10.1111/j.1600-0560.2009.01370.x DO - 10.1111/j.1600-0560.2009.01370.x ID - Albores-Saavedra2010 ER - TY - JOUR AU - Heath, M. AU - Jaimes, N. AU - Lemos, B. AU - Mostaghimi, A. AU - Wang, L. C. AU - Penas, P. F. AU - Nghiem, P. PY - 2008 DA - 2008// TI - Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features JO - J Am Acad Dermatol VL - 58 UR - https://doi.org/10.1016/j.jaad.2007.11.020 DO - 10.1016/j.jaad.2007.11.020 ID - Heath2008 ER - TY - JOUR AU - Hodgson, N. C. PY - 2005 DA - 2005// TI - Merkel cell carcinoma: changing incidence trends JO - J Surg Oncol VL - 89 UR - https://doi.org/10.1002/jso.20167 DO - 10.1002/jso.20167 ID - Hodgson2005 ER - TY - JOUR AU - Fitzgerald, T. L. AU - Dennis, S. AU - Kachare, S. D. AU - Vohra, N. A. AU - Wong, J. H. AU - Zervos, E. E. PY - 2015 DA - 2015// TI - Dramatic increase in the incidence and mortality from Merkel cell carcinoma in the United States JO - Am Surg VL - 81 ID - Fitzgerald2015 ER - TY - STD TI - Becker JC: Merkel cell carcinoma. Ann Oncol 2010, 21 Suppl 7:vii81–85. ID - ref5 ER - TY - JOUR AU - Harms, K. L. AU - Healy, M. A. AU - Nghiem, P. AU - Sober, A. J. AU - Johnson, T. M. AU - Bichakjian, C. K. AU - Wong, S. L. PY - 2016 DA - 2016// TI - Analysis of prognostic factors from 9387 Merkel cell carcinoma cases forms the basis for the new 8th edition AJCC staging system JO - Ann Surg Oncol VL - 23 UR - https://doi.org/10.1245/s10434-016-5266-4 DO - 10.1245/s10434-016-5266-4 ID - Harms2016 ER - TY - JOUR AU - Schadendorf, D. AU - Lebbe, C. AU - Zur Hausen, A. AU - Avril, M. F. AU - Hariharan, S. AU - Bharmal, M. AU - Becker, J. C. PY - 2017 DA - 2017// TI - Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs JO - Eur J Cancer VL - 71 UR - https://doi.org/10.1016/j.ejca.2016.10.022 DO - 10.1016/j.ejca.2016.10.022 ID - Schadendorf2017 ER - TY - JOUR AU - Houben, R. AU - Schrama, D. AU - Becker, J. C. PY - 2009 DA - 2009// TI - Molecular pathogenesis of Merkel cell carcinoma JO - Exp Dermatol VL - 18 UR - https://doi.org/10.1111/j.1600-0625.2009.00853.x DO - 10.1111/j.1600-0625.2009.00853.x ID - Houben2009 ER - TY - JOUR AU - Hasan, S. AU - Liu, L. AU - Triplet, J. AU - Li, Z. AU - Mansur, D. PY - 2013 DA - 2013// TI - The role of postoperative radiation and chemoradiation in merkel cell carcinoma: a systematic review of the literature JO - Front Oncol VL - 3 UR - https://doi.org/10.3389/fonc.2013.00276 DO - 10.3389/fonc.2013.00276 ID - Hasan2013 ER - TY - JOUR AU - Allen, P. J. AU - Bowne, W. B. AU - Jaques, D. P. AU - Brennan, M. F. AU - Busam, K. AU - Coit, D. G. PY - 2005 DA - 2005// TI - Merkel cell carcinoma: prognosis and treatment of patients from a single institution JO - J Clin Oncol VL - 23 UR - https://doi.org/10.1200/JCO.2005.02.329 DO - 10.1200/JCO.2005.02.329 ID - Allen2005 ER - TY - JOUR AU - Garneski, K. M. AU - Nghiem, P. PY - 2007 DA - 2007// TI - Merkel cell carcinoma adjuvant therapy: current data support radiation but not chemotherapy JO - J Am Acad Dermatol VL - 57 UR - https://doi.org/10.1016/j.jaad.2007.03.011 DO - 10.1016/j.jaad.2007.03.011 ID - Garneski2007 ER - TY - JOUR AU - Feun, L. G. AU - Savaraj, N. AU - Legha, S. S. AU - Silva, E. G. AU - Benjamin, R. S. AU - Burgess, M. A. PY - 1988 DA - 1988// TI - Chemotherapy for metastatic Merkel cell carcinoma. Review of the M.D. Anderson Hospital's experience JO - Cancer VL - 62 UR - https://doi.org/3.0.CO;2-J DO - 3.0.CO;2-J ID - Feun1988 ER - TY - JOUR AU - Pollack, S. V. AU - Goslen, J. B. PY - 1982 DA - 1982// TI - Small-cell neuroepithelial tumor of skin: a Merkel-cell neoplasm JO - J Dermatol Surg Oncol VL - 8 UR - https://doi.org/10.1111/j.1524-4725.1982.tb00248.x DO - 10.1111/j.1524-4725.1982.tb00248.x ID - Pollack1982 ER - TY - JOUR AU - Iyer, J. G. AU - Blom, A. AU - Doumani, R. AU - Lewis, C. AU - Tarabadkar, E. S. AU - Anderson, A. AU - Ma, C. AU - Bestick, A. AU - Parvathaneni, U. AU - Bhatia, S. AU - Nghiem, P. PY - 2016 DA - 2016// TI - Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma JO - Cancer Med VL - 5 UR - https://doi.org/10.1002/cam4.815 DO - 10.1002/cam4.815 ID - Iyer2016 ER - TY - JOUR AU - Pardoll, D. M. PY - 2012 DA - 2012// TI - The blockade of immune checkpoints in cancer immunotherapy JO - Nat Rev Cancer VL - 12 UR - https://doi.org/10.1038/nrc3239 DO - 10.1038/nrc3239 ID - Pardoll2012 ER - TY - JOUR AU - Leach, D. R. AU - Krummel, M. F. AU - Allison, J. P. PY - 1996 DA - 1996// TI - Enhancement of antitumor immunity by CTLA-4 blockade JO - Science VL - 271 UR - https://doi.org/10.1126/science.271.5256.1734 DO - 10.1126/science.271.5256.1734 ID - Leach1996 ER - TY - JOUR AU - Hodi, F. S. AU - O'Day, S. J. AU - McDermott, D. F. AU - Weber, R. W. AU - Sosman, J. A. AU - Haanen, J. B. AU - Gonzalez, R. AU - Robert, C. AU - Schadendorf, D. AU - Hassel, J. C. PY - 2010 DA - 2010// TI - Improved survival with ipilimumab in patients with metastatic melanoma JO - N Engl J Med VL - 363 UR - https://doi.org/10.1056/NEJMoa1003466 DO - 10.1056/NEJMoa1003466 ID - Hodi2010 ER - TY - JOUR AU - Postow, M. A. AU - Callahan, M. K. AU - Wolchok, J. D. PY - 2015 DA - 2015// TI - Immune checkpoint blockade in Cancer therapy JO - J Clin Oncol VL - 33 UR - https://doi.org/10.1200/JCO.2014.59.4358 DO - 10.1200/JCO.2014.59.4358 ID - Postow2015 ER - TY - JOUR AU - Formica, M. AU - Basolo, B. AU - Funaro, L. AU - Mazzucco, G. AU - Segoloni, G. P. AU - Piccoli, G. PY - 1994 DA - 1994// TI - Merkel cell carcinoma in renal transplant recipient JO - Nephron VL - 68 UR - https://doi.org/10.1159/000188415 DO - 10.1159/000188415 ID - Formica1994 ER - TY - JOUR AU - Penn, I. AU - First, M. R. PY - 1999 DA - 1999// TI - Merkel's cell carcinoma in organ recipients: report of 41 cases JO - Transplantation VL - 68 UR - https://doi.org/10.1097/00007890-199912150-00015 DO - 10.1097/00007890-199912150-00015 ID - Penn1999 ER - TY - JOUR AU - Engels, E. A. AU - Frisch, M. AU - Goedert, J. J. AU - Biggar, R. J. AU - Miller, R. W. PY - 2002 DA - 2002// TI - Merkel cell carcinoma and HIV infection JO - Lancet VL - 359 UR - https://doi.org/10.1016/S0140-6736(02)07668-7 DO - 10.1016/S0140-6736(02)07668-7 ID - Engels2002 ER - TY - JOUR AU - Howard, R. A. AU - Dores, G. M. AU - Curtis, R. E. AU - Anderson, W. F. AU - Travis, L. B. PY - 2006 DA - 2006// TI - Merkel cell carcinoma and multiple primary cancers JO - Cancer Epidemiol Biomark Prev VL - 15 UR - https://doi.org/10.1158/1055-9965.EPI-05-0895 DO - 10.1158/1055-9965.EPI-05-0895 ID - Howard2006 ER - TY - JOUR AU - Sibley, R. K. AU - Dehner, L. P. AU - Rosai, J. PY - 1985 DA - 1985// TI - Primary neuroendocrine (Merkel cell?) carcinoma of the skin. I. A clinicopathologic and ultrastructural study of 43 cases JO - Am J Surg Pathol VL - 9 UR - https://doi.org/10.1097/00000478-198502000-00004 DO - 10.1097/00000478-198502000-00004 ID - Sibley1985 ER - TY - JOUR AU - Silva, E. G. AU - Mackay, B. AU - Goepfert, H. AU - Burgess, M. A. AU - Fields, R. S. PY - 1984 DA - 1984// TI - Endocrine carcinoma of the skin (Merkel cell carcinoma) JO - Pathol Annu VL - 19 ID - Silva1984 ER - TY - JOUR AU - Mott, R. T. AU - Smoller, B. R. AU - Morgan, M. B. PY - 2004 DA - 2004// TI - Merkel cell carcinoma: a clinicopathologic study with prognostic implications JO - J Cutan Pathol VL - 31 UR - https://doi.org/10.1111/j.0303-6987.2004.00149.x DO - 10.1111/j.0303-6987.2004.00149.x ID - Mott2004 ER - TY - JOUR AU - Paulson, K. G. AU - Iyer, J. G. AU - Tegeder, A. R. AU - Thibodeau, R. AU - Schelter, J. AU - Koba, S. AU - Schrama, D. AU - Simonson, W. T. AU - Lemos, B. D. AU - Byrd, D. R. PY - 2011 DA - 2011// TI - Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival JO - J Clin Oncol VL - 29 UR - https://doi.org/10.1200/JCO.2010.30.6308 DO - 10.1200/JCO.2010.30.6308 ID - Paulson2011 ER - TY - JOUR AU - Chen, K. T. AU - Papavasiliou, P. AU - Edwards, K. AU - Zhu, F. AU - Perlis, C. AU - Wu, H. AU - Turaka, A. AU - Berger, A. AU - Farma, J. M. PY - 2013 DA - 2013// TI - A better prognosis for Merkel cell carcinoma of unknown primary origin JO - Am J Surg VL - 206 UR - https://doi.org/10.1016/j.amjsurg.2013.02.005 DO - 10.1016/j.amjsurg.2013.02.005 ID - Chen2013 ER - TY - JOUR AU - Tarantola, T. I. AU - Vallow, L. A. AU - Halyard, M. Y. AU - Weenig, R. H. AU - Warschaw, K. E. AU - Weaver, A. L. AU - Roenigk, R. K. AU - Brewer, J. D. AU - Otley, C. C. PY - 2013 DA - 2013// TI - Unknown primary Merkel cell carcinoma: 23 new cases and a review JO - J Am Acad Dermatol VL - 68 UR - https://doi.org/10.1016/j.jaad.2012.07.035 DO - 10.1016/j.jaad.2012.07.035 ID - Tarantola2013 ER - TY - JOUR AU - Fields, R. C. AU - Busam, K. J. AU - Chou, J. F. AU - Panageas, K. S. AU - Pulitzer, M. P. AU - Allen, P. J. AU - Kraus, D. H. AU - Brady, M. S. AU - Coit, D. G. PY - 2011 DA - 2011// TI - Five hundred patients with Merkel cell carcinoma evaluated at a single institution JO - Ann Surg VL - 254 UR - https://doi.org/10.1097/SLA.0b013e31822c5fc1 DO - 10.1097/SLA.0b013e31822c5fc1 ID - Fields2011 ER - TY - JOUR AU - Feng, H. AU - Shuda, M. AU - Chang, Y. AU - Moore, P. S. PY - 2008 DA - 2008// TI - Clonal integration of a polyomavirus in human Merkel cell carcinoma JO - Science VL - 319 UR - https://doi.org/10.1126/science.1152586 DO - 10.1126/science.1152586 ID - Feng2008 ER - TY - JOUR AU - Bhatia, S. AU - Afanasiev, O. AU - Nghiem, P. PY - 2011 DA - 2011// TI - Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer JO - Curr Oncol Rep VL - 13 UR - https://doi.org/10.1007/s11912-011-0197-5 DO - 10.1007/s11912-011-0197-5 ID - Bhatia2011 ER - TY - STD TI - Schadendorf D, Nghiem P, Bhatia S, Hauschild A, Saiag P, Mahnke L, Hariharan S, Kaufman HL. Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma. OncoImmunology. 2017:e1338237. ID - ref32 ER - TY - JOUR AU - Goh, G. AU - Walradt, T. AU - Markarov, V. AU - Blom, A. AU - Riaz, N. AU - Doumani, R. AU - Stafstrom, K. AU - Moshiri, A. AU - Yelistratova, L. AU - Levinsohn, J. PY - 2016 DA - 2016// TI - Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy JO - Oncotarget VL - 7 UR - https://doi.org/10.18632/oncotarget.6494 DO - 10.18632/oncotarget.6494 ID - Goh2016 ER - TY - JOUR AU - Lipson, E. J. AU - Vincent, J. G. AU - Loyo, M. AU - Kagohara, L. T. AU - Luber, B. S. AU - Wang, H. AU - Xu, H. AU - Nayar, S. K. AU - Wang, T. S. AU - Sidransky, D. PY - 2013 DA - 2013// TI - PD-L1 expression in the Merkel cell carcinoma microenvironment: association with inflammation, Merkel cell polyomavirus and overall survival JO - Cancer Immunol Res VL - 1 UR - https://doi.org/10.1158/2326-6066.CIR-13-0034 DO - 10.1158/2326-6066.CIR-13-0034 ID - Lipson2013 ER - TY - JOUR AU - Nghiem, P. T. AU - Bhatia, S. AU - Lipson, E. J. AU - Kudchadkar, R. R. AU - Miller, N. J. AU - Annamalai, L. AU - Berry, S. AU - Chartash, E. K. AU - Daud, A. AU - Fling, S. P. PY - 2016 DA - 2016// TI - PD-1 blockade with Pembrolizumab in advanced Merkel-cell carcinoma JO - N Engl J Med VL - 374 UR - https://doi.org/10.1056/NEJMoa1603702 DO - 10.1056/NEJMoa1603702 ID - Nghiem2016 ER - TY - STD TI - Merkel cell carcinoma guidelines [www.nccn.org/professionals/physician_gls/PDF/mcc.pdf.] UR - http://www.nccn.org/professionals/physician_gls/PDF/mcc.pdf ID - ref36 ER - TY - JOUR AU - Garon, E. B. AU - Rizvi, N. A. AU - Hui, R. AU - Leighl, N. AU - Balmanoukian, A. S. AU - Eder, J. P. AU - Patnaik, A. AU - Aggarwal, C. AU - Gubens, M. AU - Horn, L. PY - 2015 DA - 2015// TI - Pembrolizumab for the treatment of non-small-cell lung cancer JO - N Engl J Med VL - 372 UR - https://doi.org/10.1056/NEJMoa1501824 DO - 10.1056/NEJMoa1501824 ID - Garon2015 ER - TY - STD TI - Chin K, Chand VK, Nuyten DS. Avelumab: clinical trial innovation and collaboration to advance anti-PD-L1 immunotherapy. Ann Oncol. 2017; ID - ref38 ER - TY - JOUR AU - Kaufman, H. L. AU - Russell, J. AU - Hamid, O. AU - Bhatia, S. AU - Terheyden, P. AU - D'Angelo, S. P. AU - Shih, K. C. AU - Lebbe, C. AU - Linette, G. P. AU - Milella, M. PY - 2016 DA - 2016// TI - Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial JO - Lancet Oncol VL - 17 UR - https://doi.org/10.1016/S1470-2045(16)30364-3 DO - 10.1016/S1470-2045(16)30364-3 ID - Kaufman2016 ER - TY - STD TI - Kaufman HL, Russell JS, Hamid O, Bhatia ST P., D’Angelo SP, Shih KC, Lebbé CM M., Brownell I, Lewis KD, Lorch JHH A., et al: Durable responses to avelumab (anti–PD-L1) in patients with Merkel cell carcinoma progressed after chemotherapy: 1-year efficacy update. In American Association for Cancer Research annual meeting; 2017. ID - ref40 ER - TY - STD TI - D'Angelo SP, Russell J, Hassel JC, Lebbe C, Chmielowski B, Rabinowits G, Terheyden P, Brownell I, Zwiener I, Bajars M. First-line (1L) avelumab treatment in patients (pts) with metastatic Merkel cell carcinoma (mMCC): preliminary data from an ongoing study. Proc Am Soc Clin Oncol. 2017; ID - ref41 ER - TY - JOUR AU - Cowey, C. L. AU - Mahnke, L. AU - Espirito, J. AU - Fox, P. AU - Helwig, C. AU - Oksen, D. AU - Bharmal, M. PY - 2017 DA - 2017// TI - Real-world outcomes of patients with metastatic Merkel cell carcinoma treated with second-line or later chemotherapy in a community oncology setting in the United States JO - Value Health VL - 19 UR - https://doi.org/10.1016/j.jval.2016.09.2122 DO - 10.1016/j.jval.2016.09.2122 ID - Cowey2017 ER - TY - STD TI - Becker J, Lorenz E, Haas G, Helwig C, Oksen D, Mahnke L, Bharmal M. Evaluation of real world treatment outcomes in patients with metastatic merkel cell carcinoma (MCC) following second line chemotherapy. Ann Oncol. 2016;27:–1154P. 1154P ID - ref43 ER - TY - STD TI - Topalian SL, Bhatia S, Hollebecque A, Awada A, Boer JPD, Kudchadkar RR, Goncalves A, Delord J-P, Martens UM, Picazo JML, et al: Abstract CT074: non-comparative, open-label, multiple cohort, phase 1/2 study to evaluate nivolumab (NIVO) in patients with virus-associated tumors (CheckMate 358): efficacy and safety in Merkel cell carcinoma (MCC). Cancer Res 2017, 77:CT074-CT074. ID - ref44 ER - TY - STD TI - Winkler JK, Dimitrakopoulou-Strauss A, Sachpekidis C, Enk A, Hassel JC. Ipilimumab has efficacy in metastatic Merkel cell carcinoma: a case series of five patients. J Eur Acad Dermatol Venereol. 2017; ID - ref45 ER - TY - BOOK PY - 2017 DA - 2017// TI - Inc. PB - MA CY - Rockland ID - ref46 ER - TY - JOUR AU - Sharma, P. AU - Allison, J. P. PY - 2015 DA - 2015// TI - The future of immune checkpoint therapy JO - Science VL - 348 UR - https://doi.org/10.1126/science.aaa8172 DO - 10.1126/science.aaa8172 ID - Sharma2015 ER - TY - STD TI - Bhatia S, Storer BE, Iyer JG, Moshiri A, Parvathaneni U, Byrd D, Sober AJ, Sondak VK, Gershenwald JE, Nghiem P. Adjuvant radiation therapy and chemotherapy in Merkel cell carcinoma: survival analyses of 6908 cases from the National Cancer Data Base. J Natl Cancer Inst. 2016;108 ID - ref48 ER - TY - STD TI - Weber J, Mandala M, Del Vecchio M, Gogas HJ, Arance AM, Cowey CL, Dalle S, Schenker M, Chiarion-Sileni V, Marquez-Rodas I, et al: Adjuvant Nivolumab versus Ipilimumab in resected stage III or IV melanoma. N Engl J Med 2017, 377:1824–1835. ID - ref49 ER - TY - STD TI - Rozeman EA, Blank CU, Akkooi ACJV, Kvistborg P, Fanchi L, Thienen JVV, Stegenga B, Lamon B, Haanen JBAG, Schumacher T: Neoadjuvant ipilimumab + nivolumab (IPI+NIVO) in palpable stage III melanoma: updated data from the OpACIN trial and first immunological analyses. J Clin Oncol 2017, 35:9586–9586. ID - ref50 ER - TY - CHAP AU - Ledford, H. PY - 2017 DA - 2017// TI - Support for risky cancer therapy. NATURE PUBLISHING GROUP MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW BT - ENGLAND ID - Ledford2017 ER - TY - JOUR AU - Griggs, R. C. AU - Batshaw, M. AU - Dunkle, M. AU - Gopal-Srivastava, R. AU - Kaye, E. AU - Krischer, J. AU - Nguyen, T. AU - Paulus, K. AU - Merkel, P. A. PY - 2009 DA - 2009// TI - Rare diseases clinical research N: clinical research for rare disease: opportunities, challenges, and solutions JO - Mol Genet Metab VL - 96 UR - https://doi.org/10.1016/j.ymgme.2008.10.003 DO - 10.1016/j.ymgme.2008.10.003 ID - Griggs2009 ER - TY - CHAP AU - D’Angelo, S. P. AU - Russell, J. AU - Hassel, J. AU - Lebbe, C. AU - Chmielowski, B. AU - Rabinowits, G. AU - Terheyden, P. AU - Brownell, I. AU - Zwiener, I. AU - Bajars, M. PY - 2017 DA - 2017// TI - Avelumab treatment in chemotherapy-na ̈ıve patients with distant metastatic Merkel cell carcinoma (mMCC) BT - European Society for Medical Oncology 2017 congress scientific committee; September 8–12 PB - Madrid CY - Spain ID - D’Angelo2017 ER -