Fig. 4

HER2 CAR T cells can effectively treat medulloblastoma in a second orthotopic model. a Outline of experimental setup. NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice were given tumor and treated with human CAR T cells IV or IT as shown, at one of two dose levels. Bioluminescent imaging was performed using a Xenogen IVIS apparatus twice per week. b Tumor growth curves for NSG mice with previously described treatments on Day 0. Error bars represent standard error of the mean. For shown statistics, linear regressions were fitted to each curve and slopes were compared using an ANOVA test. c BLI images of mice from each group at selected timepoints. Indicated doses represent number of CAR positive T cells injected per mouse