Table 2 Prediction performance for studied biomarkers
From: Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden
Prediction Method | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|
Response Score (Training Dataset) | 95.2% | 74.1% | 74.1% | 95.2% | 83.33% |
Response Score (Test Dataset) | 72.2% | 81.8% | 86.70% | 64.30% | 75.86% |
Response Score (Combined) | 84.6% | 76.3% | 78.60% | 82.90% | 80.52% |
PD-L1 IHC (1% TPS) | 34.2% | 86.8% | 72.20% | 56.90% | 60.53% |
Mutational Burden | 32.50% | 78.90% | 61.90% | 52.60% | 55.13% |