Fig. 4

Mean (± 95% CI) fold changes in plasma Kyn at (a) Cycle 1, Day 1 and (b) Cycle 1, Day 21, relative to Day 1 predose levels after a single oral dose of navoximod. Gray ribbons represent 95% confidence intervals, and dashed horizontal lines represent no change from baseline. The significance of the Kyn changes from baseline is indicated by the 95% confidence intervals relative to the horizontal lines representing no change. If the confidence interval does not overlap with the no change reference line, then the change is significant in the context of a 95% confidence interval