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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

Fig. 4

Galunisertib anti-tumor activity in the 4T1-LP model is CD8 T cell dependent. a Mean tumor growth curves for Rag−/− mice injected orthotopically in the mammary fat pad with 4T1-LP tumor cells and treated with galunisertib (75 mg/kg BID × 28 days) when tumors reached ~ 300 mm3 (8 days after implantation). b Mean tumor growth curves for Balb/c mice injected orthotopically in the mammary fat pad with 4 T1-LP tumor cells and treated with galunisertib (75 mg/kg BID × 28 days) plus depleting antibody for CD8α (200 μg/mouse). Treatment was initiated when tumors reached ~ 300 mm3 (8 days after implantation). CD8α monoclonal antibody was injected on day 1, 2 and 3 after tumor challenge, followed by injection weekly throughout the experiment. Data represent two independent experiments with 8 mice/group

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