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Fig. 6 | Journal for ImmunoTherapy of Cancer

Fig. 6

From: Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

Fig. 6

Combination of galunisertib and anti-PD-L1 checkpoint blockade induces an intra-tumor immune related gene expression profile that is accelerated and enhanced compared to anti-PD-L1 monotherapy. Log2 Fold Change in gene expression of galunisertib (75 mg/kg BID for 28 days) and/or anti-PD-L1 (500 μg/dose, q7dx3) treated CT26 tumors against vehicle control. Differential expression and p-value was evaluated by two-way ANOVA testing. Labelled and highlighted genes are log2FC > 1, p-value< 0.05, are shown in Volcano Plots (a) and Venn Diagrams (b). Tumors were harvested and analyzed at different time points after tumor challenge: day 10, 16 and 22 (treatments were initiated at 6 days after implantation)

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