Skip to main content

Table 1 Custom designed Quantigene™ gene panel to detect T cell activation and intra-tumoral inflammation

From: Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

Cell type-specific markers

Coinhibitory & Costimulatory

Cytokines & Chemokines

Immunosuppressive Enzymes

Markers of T cell activation

Angiogenesis; Endothelial activation

EMT markers

TGFb pathway

HKGs

Cd14

4632428N05Rik (Vista)

Ccl2 (MCP-1)

Arg1

Cd69

Cdh5

Cdh1

Smad4

Gus

Cd3e

Cd200r1

Ccl3 (MIP-1a)

Ido1

Gzmb

Hif1a

Epcam

Tgfb1

Hprt

Cd4

Cd274 (PD-L1)

Ccl4 (MIP-1b)

Mpo

Ifng

Vcam1

Fap

Tgfb2

Ppib

CD68

Cd40lg

Ccl5 (RANTES)

Nos2

 

Vegfa

Snai1

Tgfb3

Rps18

Cd8b1

Cd86

Csf2 (GM-CSF)

Tdo2

 

Vegfc

Twist1

Tgfbr1

 

Foxp3

Havcr2 (TIM3)

Cxcl1

  

Icam1 (CD54)

Vim

Tgfbr2

 

Itgam (CD11B)

Icos

Ifna2

  

Sele

Cspg4

  

Itgax (CD11C)

Lag3

Ifnb1

      

Klrk1

Pdcd1 (PD-1)

Il10 (CSIF)

      

Ms4a1

Pdcd1lg2 (PD-L2)

Il13

      

Ptprc (CD45)

Pvr

Il17a

      
 

Pvrl2

Il2

      
 

Tigit

Il4

      
 

Timd4 (TIM4)

Il5

      
 

Tnfrsf18 (GITR)

Il6

      
 

Tnfrsf4 (OX40)

Il9

      
 

Tnfrsf9 (4-1BB)

Tnf

      
 

Tnfsf18 (GITRL)

       
 

Tnfsf4

       
 

Tnfsf9 (CD137L, 4-1BBL)