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Table 1 Custom designed Quantigene™ gene panel to detect T cell activation and intra-tumoral inflammation

From: Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

Cell type-specific markers Coinhibitory & Costimulatory Cytokines & Chemokines Immunosuppressive Enzymes Markers of T cell activation Angiogenesis; Endothelial activation EMT markers TGFb pathway HKGs
Cd14 4632428N05Rik (Vista) Ccl2 (MCP-1) Arg1 Cd69 Cdh5 Cdh1 Smad4 Gus
Cd3e Cd200r1 Ccl3 (MIP-1a) Ido1 Gzmb Hif1a Epcam Tgfb1 Hprt
Cd4 Cd274 (PD-L1) Ccl4 (MIP-1b) Mpo Ifng Vcam1 Fap Tgfb2 Ppib
CD68 Cd40lg Ccl5 (RANTES) Nos2   Vegfa Snai1 Tgfb3 Rps18
Cd8b1 Cd86 Csf2 (GM-CSF) Tdo2   Vegfc Twist1 Tgfbr1  
Foxp3 Havcr2 (TIM3) Cxcl1    Icam1 (CD54) Vim Tgfbr2  
Itgam (CD11B) Icos Ifna2    Sele Cspg4   
Itgax (CD11C) Lag3 Ifnb1       
Klrk1 Pdcd1 (PD-1) Il10 (CSIF)       
Ms4a1 Pdcd1lg2 (PD-L2) Il13       
Ptprc (CD45) Pvr Il17a       
  Pvrl2 Il2       
  Tigit Il4       
  Timd4 (TIM4) Il5       
  Tnfrsf18 (GITR) Il6       
  Tnfrsf4 (OX40) Il9       
  Tnfrsf9 (4-1BB) Tnf       
  Tnfsf18 (GITRL)        
  Tnfsf4        
  Tnfsf9 (CD137L, 4-1BBL)