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Table 1 Comparison of mean exposure (AUC0-last) in mouse, dog and human based following intravenous administration of pixatimod

From: Immunomodulatory activities of pixatimod: emerging nonclinical and clinical data, and its potential utility in combination with PD-1 inhibitors

Species Dose (mg/kg) HEDa / human dose (mg) AUC0-last (μg.h/mL) b Week 1 AUC0-last (μg.h/mL) b Week 4
Mouse 15 73 1358 c N.D.
Dog 2.5 83 697 1372
7.5 250 1809 4936
20 666 6883 10,536
Human 25 465 610
50 709 1688
100 1209 2381
150 1441 2781
  1. aHED – Human equivalent dose conversion (https://www.fda.gov/downloads/drugs/guidances/ucm078932.pdf)
  2. bArea under the pixatimod concentration-time curve from time 0 h (relative to applicable dose) to the last measureable concentration over the dosing interval; derived from the measured concentration values using linear trapezoidal summation
  3. cOriginally published in [29]
  4. N.D. Not Determined