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Table 1 Comparison of mean exposure (AUC0-last) in mouse, dog and human based following intravenous administration of pixatimod

From: Immunomodulatory activities of pixatimod: emerging nonclinical and clinical data, and its potential utility in combination with PD-1 inhibitors

Species

Dose (mg/kg)

HEDa / human dose (mg)

AUC0-last (μg.h/mL) b Week 1

AUC0-last (μg.h/mL) b Week 4

Mouse

15

73

1358 c

N.D.

Dog

2.5

83

697

1372

7.5

250

1809

4936

20

666

6883

10,536

Human

–

25

465

610

–

50

709

1688

–

100

1209

2381

–

150

1441

2781

  1. aHED – Human equivalent dose conversion (https://www.fda.gov/downloads/drugs/guidances/ucm078932.pdf)
  2. bArea under the pixatimod concentration-time curve from time 0 h (relative to applicable dose) to the last measureable concentration over the dosing interval; derived from the measured concentration values using linear trapezoidal summation
  3. cOriginally published in [29]
  4. N.D. Not Determined