Species | Dose (mg/kg) | HEDa / human dose (mg) | AUC0-last (μg.h/mL) b Week 1 | AUC0-last (μg.h/mL) b Week 4 |
---|---|---|---|---|
Mouse | 15 | 73 | 1358 c | N.D. |
Dog | 2.5 | 83 | 697 | 1372 |
7.5 | 250 | 1809 | 4936 | |
20 | 666 | 6883 | 10,536 | |
Human | – | 25 | 465 | 610 |
– | 50 | 709 | 1688 | |
– | 100 | 1209 | 2381 | |
– | 150 | 1441 | 2781 |