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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Enhanced susceptibility of cancer cells to oncolytic rhabdo-virotherapy by expression of Nodamura virus protein B2 as a suppressor of RNA interference

Fig. 4

VSV∆51-B2 enhances replication and cytokine levels within in vivo tumour models. a Viral titers obtained 24 hpi from subcutaneous M14 or RENCA tumours. Virus was administered intratumourally at a dose of 1E9 pfu of VSVΔ51-GFP or VSVΔ51-B2. NS: P > 0.1, *P < 0.1, **P < 0.01, ***P < 0.001, using Student’s t-test. Only significantly different pairs are indicated on the fig. b Serum levels of TNF-α, MCP-1, IL-6 and IFN-γ from RENCA tumour-bearing C57BL/6 mice. Virus was administered intratumourally at a dose of 1E9 pfu of VSVΔ51-GFP or VSVΔ51-B2 and serum collected 24 hpi. NS: P > 0.1, *P < 0.1, **P < 0.01, ***P < 0.001, using Student’s t-test. Only significantly different pairs are indicated on the figure

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