Fig. 5

Algorithm genes depend more on TIS score than on cancer type. a Each gene is plotted against TIS score, with separate lowess lines fit for each cancer type. Immune-derived tumors are highlighted; other solid tumors are shown with grey lines. A gene with no dependency on tumor type would have the same association with TIS score in each cancer type, and the lines for each cancer type would be perfectly overlapping. A gene with problematic dependency on cancer type would have lines with markedly different slopes, intercepts, or shapes. b Samples are ordered from lowest to highest TIS score. The top color bar shows TIS score