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Table 1 Genes in the Tumor Inflammation Signature

From: Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)

TIS Biology Gene Protein Function
Antigen Presenting Cell Abundance PSMB10 PSB10 Immunoproteosome Subunit
HLA-DQA1 MHC class II DQA1 MHC Class II Antigen Presentation
HLA-DRB1 MHC class II DRB1 MHC Class II Antigen Presentation
CMKLR1 CML1 Chemokine Receptor
T Cell/ NK Cell Abundance HLA-E HLAE Nonclassical Class I Antigen Presentation
NKG7 NKG7 Cytolytic Granule Protein
CD8A CD8A MHC Class I Coreceptor
IFN Activity CCL5 CCL5 Monocytes and Memory T cells Chemoattractant
CXCL9 CXCL9 Lymphocyte Chemoattractant
CD27 CD27 Lymphocyte Activation
CXCR6 CXCR6 T cell Activation
IDO1 IDO Inhibitor of T cell Proliferation and Function
STAT1 STAT1 Transcription Factor Mediating IFN Response
T Cell Exhaustion TIGIT TIGIT Inhibitor of T cell Function
LAG3 LAG3 Inhibitor of T cell Function
CD274 PD-L1 Inhibitor of T cell Function
PDCD1LG2 PD-L2 Inhibitor of T cell Function
CD276 B7-H3 Inhibitor of T cell Function
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