Skip to main content

Table 1 Genes in the Tumor Inflammation Signature

From: Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)

TIS Biology

Gene

Protein

Function

Antigen Presenting Cell Abundance

PSMB10

PSB10

Immunoproteosome Subunit

HLA-DQA1

MHC class II DQA1

MHC Class II Antigen Presentation

HLA-DRB1

MHC class II DRB1

MHC Class II Antigen Presentation

CMKLR1

CML1

Chemokine Receptor

T Cell/ NK Cell Abundance

HLA-E

HLAE

Nonclassical Class I Antigen Presentation

NKG7

NKG7

Cytolytic Granule Protein

CD8A

CD8A

MHC Class I Coreceptor

IFN Activity

CCL5

CCL5

Monocytes and Memory T cells Chemoattractant

CXCL9

CXCL9

Lymphocyte Chemoattractant

CD27

CD27

Lymphocyte Activation

CXCR6

CXCR6

T cell Activation

IDO1

IDO

Inhibitor of T cell Proliferation and Function

STAT1

STAT1

Transcription Factor Mediating IFN Response

T Cell Exhaustion

TIGIT

TIGIT

Inhibitor of T cell Function

LAG3

LAG3

Inhibitor of T cell Function

CD274

PD-L1

Inhibitor of T cell Function

PDCD1LG2

PD-L2

Inhibitor of T cell Function

CD276

B7-H3

Inhibitor of T cell Function