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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

Fig. 1

Cultured KIL cells express NK cell surface markers and lyse target cells more efficiently that sorted wild-type NK. a KIL cells, sorted WT B6 NK cells and total splenocytes were analyzed for expression of cell surface markers by flow cytometry. Percent cells positive based on isotype staining. Dead cells excluded from analysis via 7AAD positivity. b Target (YAC) cell lysis by cultured KIL or sorted WT B6 NK cells at different E:T ratios was assessed via indium release assay (12-h data shown). Three independent assays performed with similar results. * indicates significantly enhanced killing with KIL cells compared to sorted WT B6 NK cells. *, p < 0.05

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