Complete response to ipilimumab and nivolumab therapy in a patient with extensive extrapulmonary high-grade small cell carcinoma of the pancreas and HIV infection

Table 1 Safety and efficacy of HIV positive patients treated with immune checkpoint inhibitors

Study	No of patients with HIV	Disease	Viral response	Disease response
Rai et al. 2017 [20]	11	8 Melanoma, 1 HCC, 1 RCC, 1 BC	No pt. had loss in viral control or immune reconstitution inflammatory syndrome	2 CR, 1 PR, 4 SD, 4PD
Heppt et al. 2017 [19]	10	Melanoma	No increase in viral load, no effect on CD4 count
Wightman et al. 2015 [18]	1	Melanoma	Improved CD4 count and decrease in Viral load	NA
Burke et al. 2011 [9]	1	Melanoma	Stable CD 4 count and viral load	PR
Morris et al. 2017 [14]	2	Anal cancer	Stable CD4 count and viral load	NA
Sandoval-Sus et al. 2017 [16]	1	Hodgkin lymphoma	Stable CD4 count and viral load	PR
Tomsitz et al. 2017 [17]	1	Melanoma	Stable CD4 count and viral load	PR
Ruzevick et al. 2013 [15]	1	Melanoma	Stable CD4 count and viral load	PR
Davar et al. 2015 [10]	1	Melanoma	Stable CD4 count and viral load	PD
Le Garff et al. 2017 [12]	1	NSCLC	CD4 count increased with stable viral load	PD
Guihot et al. 2017 [6]	1	NSCLC	Stable CD4 count and viral load	PR
Samri et al. 2017 [7]	12	NSCLC	Stable CD4 count and viral load	3 PR, 4 SD, 5 PD
Hentrich et al. 2017 [11]	1	NSCLC	CD4 count decreased but viral load remained stable	PD
McCullar et al. 2017 [13]	1	NSCLC	CD4 count decreased but viral load remained stable	CR
Uldrick et al. 2017 (NCT02595866)	17	Mix	Increase in CD4 count, viral load remained suppressed	NA

Abbreviations: HCC hepatocellular carcinoma, RCC renal cell carcinoma; BC bladder carcinoma, CR complete response, PR partial response, SD stable disease, PD progressive disease, NSCLC non-small cell lung cancer