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Table 1 Safety and efficacy of HIV positive patients treated with immune checkpoint inhibitors

From: Complete response to ipilimumab and nivolumab therapy in a patient with extensive extrapulmonary high-grade small cell carcinoma of the pancreas and HIV infection

Study No of patients with HIV Disease Viral response Disease response
Rai et al. 2017 [20] 11 8 Melanoma, 1 HCC, 1 RCC, 1 BC No pt. had loss in viral control or immune reconstitution inflammatory syndrome 2 CR, 1 PR, 4 SD, 4PD
Heppt et al. 2017 [19] 10 Melanoma No increase in viral load, no effect on CD4 count  
Wightman et al. 2015 [18] 1 Melanoma Improved CD4 count and decrease in Viral load NA
Burke et al. 2011 [9] 1 Melanoma Stable CD 4 count and viral load PR
Morris et al. 2017 [14] 2 Anal cancer Stable CD4 count and viral load NA
Sandoval-Sus et al. 2017 [16] 1 Hodgkin lymphoma Stable CD4 count and viral load PR
Tomsitz et al. 2017 [17] 1 Melanoma Stable CD4 count and viral load PR
Ruzevick et al. 2013 [15] 1 Melanoma Stable CD4 count and viral load PR
Davar et al. 2015 [10] 1 Melanoma Stable CD4 count and viral load PD
Le Garff et al. 2017 [12] 1 NSCLC CD4 count increased with stable viral load PD
Guihot et al. 2017 [6] 1 NSCLC Stable CD4 count and viral load PR
Samri et al. 2017 [7] 12 NSCLC Stable CD4 count and viral load 3 PR, 4 SD, 5 PD
Hentrich et al. 2017 [11] 1 NSCLC CD4 count decreased but viral load remained stable PD
McCullar et al. 2017 [13] 1 NSCLC CD4 count decreased but viral load remained stable CR
Uldrick et al. 2017 (NCT02595866) 17 Mix Increase in CD4 count, viral load remained suppressed NA
  1. Abbreviations: HCC hepatocellular carcinoma, RCC renal cell carcinoma; BC bladder carcinoma, CR complete response, PR partial response, SD stable disease, PD progressive disease, NSCLC non-small cell lung cancer