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Table 4 Examples of active clinical studies with bacteria

From: White paper on microbial anti-cancer therapy and prevention

Biological Agent Bacterium NCT# Indication
IL-2 Salmonella NCT01099631 Liver Cancer
C. novyi-NT Clostridium NCT00358397
NCT01118819
NCT01924689
Solid Tumors
APS001F Bifidobacterium NCT01562626 Solid Tumors
JNJ-64041757 Listeria NCT02592967
NCT02625857
NSCLC
Prostate Cancer
JNJ-757 Listeria NCT03371381 Lung Cancer
pLADD Listeria NCT03189030 Metastatic Colorectal Cancer
ADU-623 Listeria NCT01967758 Astrocytic Tumors
ADXS11-001 Listeria NCT01598792
NCT01266460
Oropharyngeal Cancer
Cervical Cancer
CRS-207 Listeria NCT01675765
NCT00585845
NCT02575807
Malignant Pleural Mesothelioma
Adenocarcinoma of the Pancreas
Ovarian Cancer
GVAX & CRS-207 Listeria/GVAX NCT02004262 Pancreatic Cancer
  1. In these clinical trials, Listeria do not colonize the tumor microenvironment