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Table 5 Examples of translational research support at NIH

From: White paper on microbial anti-cancer therapy and prevention

Program Mission/Objective Website link
NCI: Experimental Therapeutics (NExT) Program Supports promising new anticancer-drug (small molecule, biologics) discovery and development projects towards clinical evaluation and registration. https://next.cancer.gov/
NCI: Division of Cancer Prevention (PREVENT) Supports development in cancer prevention intervention and biomarkers. https://prevention.cancer.gov/major-programs/prevent-cancerpreclinical
NCATS: Bridging Interventional Development Gaps (BrIDGs) Program Advances promising therapeutic agents for both common and rare diseases through late-stage preclinical development toward an IND application. https://ncats.nih.gov/bridgs
NCATS: Therapeutics for Rare and Neglected Diseases (TRND) Program Supports preclinical development of therapeutic drugs to treat rare and neglected disorders toward the goal of an IND application. https://ncats.nih.gov/trnd
NIAID: Translation Resource Tools Supports preclinical and clinical research for vaccines, diagnostics, and therapeutics. https://www.niaid.nih.gov/research/therapeutic-developmentservices
NINDS: Create Bio Program Supports optimization of biotechnology product and biologics-based therapies for development and IND-enabling studies, as well as early-phase clinical trials. https://www.ninds.nih.gov/Current-Research/Research-Funded-NINDS/Translational-Research/CREATE-BIO
NHLBI: SMARTT Program Accelerates translation of research for therapeutic candidates or diagnostic imaging agents from in vivo efficacy to IND submission for treatment of heart, lung, or blood diseases. https://www.nhlbismartt.org/