Fig. 3
From: Severe hemophagocytic lymphohistiocytosis in a melanoma patient treated with ipilimumab + nivolumab
Bone marrow biopsy obtained after disease resolution. a Regenerative BM core, H&E, magnification of 500×. b BM aspirate smears showing erythroid hyperplasia with no neoplastic cells. Wright-Giemsa, magnification of 500×. Immunohistochemistry for CD34 (c) and Melan-A (d). There was no increase in CD34+ blasts, and no detectable Melan-A-positive cells, i.e. no melanoma; magnification 200×